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TGCT testis

Objective: Testicular germ cell tumour (TGCT) is a malignancy with a high heritable component. The inherited risk is polygenic, and around 50 susceptibility genes are identified. The functional role of the gene products for TGCT development is not well understood Testicular germ cell tumors (TGCT) are the most common cancer in men ages 20-40. The incidence of TGCT has more than doubled over the past forty years, without clear etiology. Both genetic effects and environmental exposures, specifically during the pre-natal period, are likely to play an important role in determining TGCT susceptibility

Known risk factors for TGCT include a history of undescended testis (UDT), testicular dysgenesis, infertility, previously diagnosed TGCT, and a family history of the disease. Brothers of men with TGCT have an 8- to 10-fold risk of developing TGCT, whereas the relative risk to fathers and sons is 4-fold Testicular Cancer. Detailed Description: Familial clustering of testicular germ cell tumors (TGCT) is well-documented, and a family history of TGCT is associated with an increased risk of this disease. The International Testicular Cancer Linkage Consortium (ITCLC) has assembled 350 multiple case TGCT families in support of a linkage effort that. Cancer-testis (CT) genes are a group of genes restrictedly expressed in testis and multiple cancers and can serve as candidate driver genes participating in the development of cancers. Our previous study identified a number of CT genes in nongerm cell tumors, but their expression pattern in testicular germ cell tumor (TGCT), a cancer type.

The incidence of metachronous germ cell tumor in the contralateral testis ranges from 1 to 5% in men affected by TGCTs, 35-38 indicating that the relative risk of developing a germ cell tumor is approximately 25-fold higher in patients with a history of TGCT than in age-matched populations. 39 The risk of contralateral TGCTs is lower in. The incidence rate of testicular germ cell tumors (TGCT) has continuously increased in Western countries over the last several decades , , , , , , . Little is known about the polychlorinated biphenyl (PCBs) exposures that could explain the observed long-term increasing trend in the U.S Surviving Testicular Cancer: The Role of the Contralateral Testicle. Metachronous contralateral testicular cancer (MCTC) after primary testicular germ cell tumor (TGCT) has emerged as a critical survivorship issue facing the young cohort of testicular cancer (TC) survivors. Treatment for MCTC usually requires surgical castration, resulting in. Testicular microlithiasis (TM) is characterised by small intratesticular calcifications, which can be visualised by ultrasound. Men with testicular germ cell tumour (TGCT) have a higher frequency. Testicular germ-cell tumours (TGCT) are the most common neoplasm in young men. Various studies have suggested the existence of an inherited predisposition to development of these tumours. Genome-wide screens subsequently provided evidence of a TGCT susceptibility gene on chromosome Xq27 (TGCT1) that might also predispose to cryptorchism

Functions of genes related to testicular germ cell tumour

TGCT : Testis germ cell tumors * Please note that boxplot is altered on 8/16/2018, with the inclusion of 46 samples associated with Stage IS to Stage I. Note Cancer stage information is not available for 23 samples In the latest study, TECAC researchers analyzed genetic data from 10,156 testicular germ cell tumor cases and 179,683 controls in the largest GWAS of TGCT to date. The study revealed 22 novel loci. When taken together, the results can explain 44 percent of the father-to-son familial risk for testicular cancer, the authors said Testicular germ cell tumors (TGCT) are the most common tumor in young white men and have a high heritability. In this study, the international Testicular Cancer Consortium assemble 10,156 and.

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Testicular cancer is the most commonly diagnosed malignancy of adult males among Americans, 7 while TGCT accounts for more than 95% of testicular cancers. 8 The main types of TGCT are seminomas and non-seminomas, and non-seminomas consist of either undifferentiated (embryonal carcinoma) or differentiated (teratoma, yolk sac tumor, and. A meta-analysis of nearly 200,000 men revealed 22 new genetic locations that could be susceptible to inherited testicular germ cell tumors (TGCT)—a 40 percent increase in the number of regions.

OMIM Entry - # 273300 - TESTICULAR GERM CELL TUMOR; TGC

The primary testis tumor was a type II TGCT, consisting of combined teratoma and seminoma of 1.4 cm comprising a stage IIIc intermediate risk non-seminoma of the testis. At that time, serum alpha-fetoprotein (AFP), human chorionic gonadotropin-beta (beta-HCG) and lactate dehydrogenase (LDH) were elevated Testicular germ cell tumor (TGCT) is the most common malignancy in males aging 15-35. Known risk factors for TGCT include: cryptorchidism, testicular dysgenesis, infertility, testicular microlithiasis, previously diagnosed TGCT and a family history of the disease [].Familial aggregations of TGCT have been well described, suggesting the existence of a hereditary TGCT subset A meta-analysis of nearly 200,000 men has revealed 22 new genetic locations that could be susceptible to inherited testicular germ cell tumors (TGCT). The findings increase by 40% the number of. Extra Genetic Markers for Inherited Testicular Most cancers. By. admin. -. August 1, 2021. 0. 1. A meta-analysis of nearly 200,000 men found 22 new genetic locations that could be prone to hereditary testicular germ cell tumors (TGCT) - a 40 percent increase in the number of regions known to be related to cancer In this review, it discusses potential mechanisms of TGCT cisplatin sensitivity and resistance to conventional chemotherapeutics. AB - Testicular germ cell tumors (TGCTs) are a cancer pharmacology success story with a majority of patients cured even in the highly advanced and metastatic setting

Testicular germ cell tumors are one of the most heritable cancers. 3 However, the inherited genomic drivers of TGCT initiation and progression are not fully characterized. Here, we build on our findings of increased DNA double-strand breaks as a unique genomic feature for TGCTs and identify inherited pathogenic DRG variants as potential genomic. More Genetic Markers for Inherited Testicular Cancer Identified. A meta-analysis of nearly 200,000 men revealed 22 new genetic locations that could be susceptible to inherited testicular germ cell tumors (TGCT) — a 40% increase in the number of regions known to be associated with the cancer. The new findings, published online in Nature. 3.2. Testicular Germ Cell Tumor vs. Healthy Testicular Tissue. As expected, almost uniform 12p chromosomal gain in 146 of 149 TGCT samples was found. As for the selected genes, alterations have been detected in eight genes (HOXA9, SOX2, KIT, MGMT, SALL4, SOX17, PRSS21, and NANOG) across 28% of the TGCT samples, with KIT alterations alone making up 15% and NANOG constituting an additional 7%. GWAS Uncovers 22 More Genetic Loci Linked to Inherited Testicular Cancer. A meta-analysis of nearly 200,000 men has revealed 22 new genetic locations that could be susceptible to inherited testicular germ cell tumors (TGCT). The findings increase by 40% the number of regions known to be associated with this type of cancer

Genetics of Familial Testicular Cancer - Full Text View

Aberrant overexpression of PIWI/piRNA pathway proteins is shown for many types of tumors. Interestingly, these proteins are downregulated in testicular germ cell tumors (TGCTs) compared to normal testis tissues. Here, we used germline and TGCT markers to assess the piRNA biogenesis and function in TGCTs and their precursor germ cell neoplasia in situ (GCNIS) A meta-analysis of almost 200,000 guys disclosed 22 brand-new hereditary areas that can be vulnerable to acquired testicular bacterium cell lumps (TGCT)- a 40 percent rise in the variety of areas recognized to be connected with the cancer cells The tgct testis tumors (D) show uniformly high expression of ziwi.(E) FACS analysis for DNA content of cultured wild-type and tgct testis on day 1. (F) FACS analysis on day 8 after culturing. Wild-type spermatogonia have completed meiosis to become haploid spermatocytes and spermatozoa (1N), but tgct tumor cells remain diploid (2N) and do no TGCT in the contralateral testicle, cryptorchidism, impaired spermatogenesis, inguinal hernia, hydrocele, disorders of sex development, prior testicular biopsy, atopy and testicular atrophy [8]. Cryptorchidism, or undescended testis, is the antecedent medical condition most closely associated. Expression of SOCS2 in TGCT based on patient's age 21 - 40 Yrs (n=104) 41 - 60 Yrs (n=18) 61 - 80 Yrs (n=2) 0 20 40 60 80 100. TGCT : Testis germ cell tumors. Note Patient age information is not available for 16 samples. Ten samples belonging to patients aged below 20 are not considered in the above plot. Show statistics

Comprehensive characterization of cancer-testis genes in

384. Background: Stage I testicular germ cell tumor (TGCT) has excellent cure rates and surveillance is fully included in patient's management, particularly during the first years of follow-up. Surveillance guidelines differ between the academic societies, with different recommendations concerning clinical and imaging frequency de-escalation and long term follow-up In this paper we review clinical and genetic aspects of testicular germ cell tumours (TGCTs). TGCT is the most common type of malignant disorder in men aged 15-40 years. Its incidence has increased sharply in recent years. Fortunately, survival of patients with TGCT has improved enormously, which can chiefly be attributed to the cisplatin-based polychemotherapy that was introduced in the. Testicular germ cell tumor (TGCT) is most frequently diagnosed in young males and its etiology remains poorly understood. Cases of newly diagnosed TGCT have been rising in the United States and incidence among African Americans (AA) has increased nearly 40%. Incidence of TGCT in native black African (BA) males, conversely, has remained low. We sought to determine the racial identification of. Testicular germ cell tumor (TGCT) is the most solid tumor in 20-40 years old man. TGCT account for 95% of testicular tumors and represent a unique type of human cancer from several different perspectives. TGCT arise by transformation of germ cells. The Transformed germ cells exhibit ploripotentially to differentiate into embryonic CT scans and X-rays may up testicular cancer risk. The steady rise in testicular germ cell tumor (TGCT) cases over the past three or four decades suggests there is an environmental exposure risk.

Current knowledge of risk factors for testicular germ cell

  1. Differential expression analysis of contigs from normal testis and TGCT samples (including CIS samples) revealed a genome-wide loss of small RNA contigs in the TGCT samples (Fig. 3a). This loss leads to the asymmetric, left-skewed shape of the volcano-plot observed in Fig. 3b , revealing an average log2 fold change of −5
  2. Tenosynovial giant cell tumor (TGCT) is a group of rare, typically non-malignant tumors of the joints. TGCT tumors often develop from the lining of joints (also known as synovial tissue).: 100: 245 Common symptoms of TGCT include swelling, pain, stiffness and reduced mobility in the affected joint or limb
  3. Recently testis biopsy has been suggested in cases where there is a combination of UDT and TM, since both are risk factors for TGCT. 18 TM has also been suggested to be an indication of manifestation of a TGCT susceptibility allele. 1
  4. As TGCT is of low frequency overall, in familial TGCT pedigrees and for the purpose of classical segregation analyses or genome-wide association studies (GWAS), testicular microlithiasis could be used to label asymptomatic individuals in pedigrees as potentially affected, enhancing the performance of GWAS

Dataset of testicular germ cell tumors (TGCT) risk

More genetic markers for inherited testicular cancer identified. By RelationshipTips On Jul 29, 2021. A meta-analysis of nearly 200,000 men revealed 22 new genetic locations that could be susceptible to inherited testicular germ cell tumors (TGCT) — a 40 percent increase in the number of regions known to be associated with the cancer Adult testis weight is often used as an indirect measure of alterations in germ cell numbers and reduced fertility is an established TGCT risk factor (56, 57). Interestingly, we observed a small but significant decrease in M19- Eif2s2 Trap /+ testis weight compared with M19 controls at 6 weeks of age (Fig. 4 A) INTRODUCTION. Testicular cancer (TC), in which malignant cells form in the tissues of one or both testicles, has an annual incidence of approximately 1% among all newly diagnosed cancers in males.1 The most common form of TC is testicular germ cell tumors (TGCT), accounting for >95% of cases, which consist of seminoma and nonseminoma subtypes.2 The overall mortality rate of TGCT remains high. A new meta-analysis increased the number of genetic locations for disease by 40 percent. A meta-analysis of nearly 200,000 men revealed 22 new genetic locations that could be susceptible to inherited testicular germ cell tumors (TGCT) — a 40 percent increase in the number of regions known to be associated with the cancer

The incidence of testicular germ cell tumors (TGCT), the most common cancer in men aged 15 to 45 years, has doubled over the last 30 years in developed countries. Reasons remain unclear but a role of environmental factors, especially during critical periods of development, is strongly suspected. Reliable data on environmental exposure during this critical time period are sparse In the latest study, TECAC researchers analyzed genetic data from 10,156 testicular germ cell tumor cases and 179,683 controls in the largest GWAS of TGCT to date. The study revealed 22 novel loci. When taken together, the results can explain 44 percent of the father-to-son familial risk for testicular cancer, the authors said

Testicular microlithiasis (TM) is one of the symptoms of testicular dysgenesis syndrome (TDS). rs6897876), BAK1 (rs210138), BMP7 (rs388286), TGFBR3 (rs12082710), and HOXD (rs17198432) in 142 TGCT patients, 137 TM patients, and 153 fertile men (control group). We found significant differences in the KITLG GG_rs995030 genotype in TM (P = 0.01. A majority of testicular cancer, 95 percent of all cases, begins in testicular germ cells, which are the cells responsible for producing sperm. Testicular germ cell tumors (TGCT) are the most common cancer in men aged 20 to 39 years in the U.S. and Europe Complex genetic factors underlie testicular germ cell tumor (TGCT) development. One experimental approach to dissect the genetics of TGCT predisposition is to use chromosome substitution strains, such as the 129.MOLF-Chr 19 (M19). M19 carries chromosome (Chr) 19 from the MOLF whereas all other chromosomes are from the 129 strain. 71% of M19 males develop TGCTs in contrast to 5% in 129 strain INTRODUCTION. Testicular germ cell tumors (TGCTs) are the most common neoplasm of adolescent and adult men ages 15 to 45 years, 1 and young survivors face significant sequelae, including elevated rates of cardiovascular disease and second primary malignancies. 2 Therefore, understanding the etiology of TGCT as the basis of prevention is an important research priority

Surviving Testicular Cancer: The Role of the Contralateral

IMPLICATIONS: TGCT is largely treatable, but treatment usually involves have the afflicted testis removed.The authors also suggest that cocaine may play a role in opposing the effects of THC. This. What does TGCT stand for? List of 12 TGCT definitions. Top TGCT abbreviation meanings updated February 202 The estimated incidence of testicular torsion in men is 4.5 per 100,000 [], and the incidence of TGCT in men during their lifetime is 5.1 per 100,000 [].TGCT with contralateral testicular torsion is still extremely rare. There have been some case reports of TGCT with ipsilateral testicular torsion, most detected after presenting with acute scrotal pain as a symptom of torsion

Testicular microlithiasis as a familial risk factor for

Genetic predisposition to testicular germ-cell tumours

Germ cell testicular cancer (TGCT), which accounts for around 95% of testicular cancer cases in the UK, is one of the most highly heritable tumour types (40% heritability estimated with population-based approaches). 5-year survival of testicular cancer is very high (above 97% for stages 1 and 2 and >80% for stages 3 and 4 testicular cancer) developing Testicular Cancer in the long term. The risk of TGCT in the Undescended Testis (UDT) is increased by 4 - 13, with up to 7-10% of Testicular Cancers developing in UDT (Schottenfeld et al., 1980). There is a 5-10% risk of developing testicular cancer in the contralateral testis in those with a history of UDT (Henderson, et al., 1979.

Differentially expressed genes between stage I testicularImmunohistochemistry of USP13 on testicular tissue, EC and

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  1. Increased incidence of TGCT: Early and repeated exposures to diagnostic imaging, such as X-rays and CT scans, may increase the risk of testicular cancer, suggests a new study from Penn Medicine researchers published online today in PLOS ONE. The steady rise in testicular germ cell tumor (TGCT) cases over the past three or four decades.
  2. TGCT: testicular germ cell tumors. Overexpression of METTL3 Promotes Migration and Invasion of TGCT Cells The effect of overexpressed METTL3 on TGCT cell migration and invasion ability was investigated using the Transwell assay, showing that the migration and invasion ability of both groups of transfected cells increased more than twofold after.
  3. omas are sensitive to both radiation and chemotherapy, whereas nonse
  4. TGCT is the rapid growth of abnormal cells in the testicles. Often men with TGCT notice a hard, painless lump on the testicle or a change in the size of their testicle. TGCTs can progress quickly in some men. Changes in the testicles that might indicate TGCT are often found through a testicular self-exam. For more information about self-exams.
  5. Testicular germ cell tumors (TGCT) are the most frequent cancers among young men. There is a clear familial component to TGCT etiology, but no high-penetrance susceptibility gene has been identified. Epigenetic aberrations of the genome represent an alternative mechanism for cancer susceptibility; and, studies suggest that epigenetic changes that influence cancer risk can be inherited through.
  6. Cryptorchidism status, family history of testicular germ cell tumor (TGCT) or other cancer, and presence of double primaries are displayed. Unk, unknown. (C) Significant recurrent mutations (KIT, KRAS, and NRAS) or curated based on frequency or biological relevance

Penn-led Consortium Identifies More Genetic Markers for

Introduction. Testicular germ cell tumors (TGCT) are the most common cancer in young men, ages 15 to 44 years ().Although it is a highly treatable cancer type, exemplified by a 10-year net survival rate of 98% in England and Wales (), the disease affects men in their prime and treatment can lead to substantially increased morbidity, including cardiovascular disease, reduced fertility, and. Interest in testicular microlithiasis has increased over the past few years, owing to an observed association with testicular germ cell tumor (TGCT) and intratubular germ cell neoplasia of unclassified type (ITGCNU). This association has added to evidence that testicular microlithiasis is a feature of the testicular dysgenesis syndrome (TDS. Testicular germ cell tumors (TGCTs) are the most common tumors in adolescent and young men. Recently, genome-wide studies have made it possible to progress in understanding the molecular mechanisms underlying the development of tumors. It is becoming increasingly clear that aberrant regulation of RNA metabolism can drive tumorigenesis and influence chemotherapeutic response Introduction. As the most common malignancy in men between 15 and 44 years of age, testicular germ cell tumors (TGCT) have been increasing over the past few decades in most populations (1,2).TGCTs can be classified by histologic subtype into three groups: seminoma, non-seminoma, and spermatocytic tumor ().Non-seminomas and seminomas together represent 98-99% of all TGCTs, and the peak. Background: Long-term relative survival (RS) data for testicular germ cell tumor (TGCT) patients are scarce. We aimed to analyze long-term RS among TGCT patients diagnosed in Norway, between 1953 and 2012. Methods: Data sources were the Cancer Registry of Norway and the Norwegian Cause of Death Registry. TGCT patients diagnosed during 1953 to 2012 were classified by time of diagnosis.

Identification of 22 susceptibility loci associated with

Background SPANX family members are thought to play an important role in cancer progression. The SPANXN2 is a gene expressed mainly in normal testis, but its role in testicular germ cell tumors (TGCTs) has yet to be investigated. TGCT is one of the most common solid tumors in young men and is associated with poor prognosis; however, effective prognostic indicators remain elusive Background: Testicular germ cell tumor (TGCT) incidence has increased over the last 40 years in the United States. In contrast to TGCT among infants, it is hypothesized that TGCT in adolescents and young men is the result of sex steroid hormone imbalance during early fetal development. However, little is known about the neonatal period when abrupt hormonal changes occur, and direct supporting. to inherited testicular germ cell tumors (TGCT)—a 40 percent increase in the number of regions known to be associated with the cancer. The new findings, published online in Natur These cancers are known as testicular germ cell tumors (TGCT). Compared with other cancers, testicular cancer is not common. In fact, a man's lifetime risk of developing it is around 1 in 263. Adolescent Latino boys in California exposed in utero to a commonly used pesticide spread in fields near their mothers' homes are at an increased risk of developing testicular germ cell cancer (TGCT), according to a study presented at a virtual meeting on cancer health disparities held October 2-4, 2020, by the American Association for Cancer Research (AACR)

Comprehensive characterization of cancer‐testis genes in

Consortium identifies more genetic markers for inherited

  1. Testicular Cancer Consortium (TECAC) Linkage studies and candidate locus studies have had limited success in identifying genetic susceptibility genes for testicular germ cell tumors (TGCT). Genome-wide association studies (GWAS), however, have identified a number of important loci, the one with the highest hazard ratio being KITLG, which.
  2. oma of the testis. At that time, serum alpha-fetoprotein (AFP), human chorionic gonadotropin-bet
  3. Rates of testicular cancer appear to be increasing rapidly over time - and yet the primary exposures involved in its aetiology remain poorly understood . In recent years, at least three case-control studies reported associations between cannabis exposure and testicular germ cell tumour (TGCT) development [7-9]
  4. Genome-wide association studies (GWAS) have identified multiple risk loci for testicular germ cell tumour (TGCT), revealing a polygenic model of disease susceptibility strongly influenced by common variation. To identify additional single-nucleotide polymorphisms (SNPs) associated with TGCT, we conducted a multistage GWAS with a combined data.
  5. Chung P, Warde P. Testicular cancer: germ cell tumours. BMJ Clin Evid. 2016;2016.). Germ cell tumors constitute 90% of all testicular cancers and serum tumor markers play a crucial rule in diagnosis, treatment and follow-up of patients with TGCT (3 3. Leman ES, Gonzalgo ML. Prognostic features and markers for testicular cancer management
  6. oma histologic subtype, a systematic review and meta-analysis found

Testicular cancer, the most common cancer in white men aged 15-44, has steadily increased in incidence in the United States over the past three or four decades: the rate has jumped from 3 out. Testicular germ cell tumour (TGCT) is the most common cancer in young men in large parts of the world, but the aetiology is mainly unknown. Genome-wide association studies have so far identified about 50 susceptibility loci associated with TGCT, including SPRY4. SPRY4 has shown tumour suppressor activity in several cancer cells, such as lung. Tumor samples were also collected from the testicular cancer patients. When adjusting for known risk factors of testicular cancer, the researchers found a 59 percent increased risk of TGCT among individuals reporting at least three exposures to diagnostic radiation below the waist, compared to men with no exposure Studies of transgenerational genetic effects on testicular cancer in mice show that Dnd1 is an essential component of a cross-generation system, with genes such as Trp53, Kitl, and Eif2s2 in the parental generation acting with Dnd1 in male offspring to increase significantly the number of TGCT-affected males and the proportion of bilateral cases

Intra-abdominal Testicular Seminoma in an Elderly MaleClinical implications of the American Joint Committee onSperm Concentration, Testicular Volume and Age Predict

Introduction. Testicular germ cell tumors (TGCTs) are the most frequent solid malignancy in young men aged between 15 and 35 years. Most of TGCTs are sporadic, but the heritability is high, and positive family history represents a well-established risk factor (Nallu et al. 2014, Rajpert-De Meyts et al. 2016).Other known risk factors are a prior TGCT, infertility, cryptorchidism and testicular. A large study of all exons of DICER1, conducted using DNA from 4 microsatellite-stable testicular germ cell tumor (TGCT) cell lines and germ-line DNA from 185 persons with a germ cell tumor (of whom 71 had a seminoma and 128 of whom had a family history of TGCT) revealed one germ-line mutation, c.4740G > T, p.Q1580H, in a man with a past.

Clare TURNBULL | Research Team Leader | MD, PhD, MSc, FRCPMarlowe MCINTYRE | University of California, Santa BarbaraAumento del volumen del hemiescroto derechoVenn diagram (http://bioinfogp